Differential activity of pro-angiogenic CXC chemokines

We showed previously in a mouse model of lung ischemia-induced angiogenesis, enhanced expression of the three ELR+ CXC chemokines (KC, LIX, and MIP-2) and that blockade of the ligand receptor CXCR2 limited neovascularization. The present study was undertaken to determine the relative abundance and a...

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Veröffentlicht in:	Microvascular research 2010-07, Vol.80 (1), p.18-22
Hauptverfasser:	Moldobaeva, Aigul, Baek, Amy, Eldridge, Lindsey, Wagner, Elizabeth M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenic Proteins - metabolism Angiogenic Proteins - pharmacology Animals Antibodies - immunology Antibodies - pharmacology Aorta - cytology Chemokine CXCL1 - metabolism Chemokine CXCL1 - pharmacology Chemokine CXCL2 - metabolism Chemokine CXCL2 - pharmacology Chemokine CXCL5 - metabolism Chemokine CXCL5 - pharmacology Chemokines Chemokines, CXC - metabolism Chemokines, CXC - pharmacology Chemotaxis - drug effects Endothelial Cells - cytology Endothelial Cells - drug effects Enzyme Inhibitors - pharmacology Ischemia - metabolism Ligation Lung - drug effects Lung - physiology Male Mice Mice, Inbred C57BL Mouse arterial endothelial cells Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Neuropeptides - antagonists & inhibitors Neuropeptides - metabolism Pulmonary Artery - surgery rac GTP-Binding Proteins - antagonists & inhibitors rac GTP-Binding Proteins - metabolism rac1 GTP-Binding Protein Receptors, Interleukin-8A - antagonists & inhibitors Receptors, Interleukin-8A - immunology Receptors, Interleukin-8B - antagonists & inhibitors Receptors, Interleukin-8B - immunology rho GTP-Binding Proteins - antagonists & inhibitors rho GTP-Binding Proteins - metabolism Tissue Culture Techniques
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Zusammenfassung:	We showed previously in a mouse model of lung ischemia-induced angiogenesis, enhanced expression of the three ELR+ CXC chemokines (KC, LIX, and MIP-2) and that blockade of the ligand receptor CXCR2 limited neovascularization. The present study was undertaken to determine the relative abundance and angiogenic potential of the three CXC chemokines and whether RhoA activation explained the measured differences in potencies. We found that LIX showed the greatest absolute amount in the in vivo model 4 h after left pulmonary artery obstruction (LIX>KC>MIP-2; p
ISSN:	0026-2862 1095-9319
DOI:	10.1016/j.mvr.2010.01.011