Association of CHRN genes with "dizziness" to tobacco

Association of CHRN genes with "dizziness" to tobacco

The neuronal nicotinic receptor genes (CHRN) have been implicated in a variety of smoking‐related behaviors. Here we tested for association between an early subjective response phenotype, “dizziness,” and 226 single nucleotide polymorphisms (SNPs) in CHRN genes. The sample included 789 nicotine‐depe...

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Veröffentlicht in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2010-03, Vol.153B (2), p.600-609
Hauptverfasser: Ehringer, Marissa A., McQueen, Matthew B., Hoft, Nicole R., Saccone, Nancy L., Stitzel, Jerry A., Wang, Jen C., Bierut, Laura J.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Case-Control Studies
Dizziness
Female
gene expression
Genetics
Haplotypes
Humans
Male
nicotinic receptors
Phenotype
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Receptors, Nicotinic - genetics
RNA - metabolism
Smoking
subjective effects
tobacco
Tobacco Products
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Beschreibung
Zusammenfassung:The neuronal nicotinic receptor genes (CHRN) have been implicated in a variety of smoking‐related behaviors. Here we tested for association between an early subjective response phenotype, “dizziness,” and 226 single nucleotide polymorphisms (SNPs) in CHRN genes. The sample included 789 nicotine‐dependent cases and 811 controls, where early “dizziness” reports were significantly associated with case/control status (P 
ISSN:1552-4841
1552-485X
1552-485X
DOI:10.1002/ajmg.b.31027