On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila

On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila

The detection of selection, both positive and negative, acting on a DNA sequence or class of nucleotide sites requires comparison with a reference sequence that is unaffected by selection. In Drosophila, recent findings of widespread selective constraint, as well as adaptive evolution, in both codin...

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Veröffentlicht in:Molecular biology and evolution 2010-06, Vol.27 (6), p.1226-1234
Hauptverfasser: Parsch, John, Novozhilov, Sergey, Saminadin-Peter, Sarah S, Wong, Karen M, Andolfatto, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Databases, Genetic
Deoxyribonucleic acid
DNA
Drosophila - genetics
Drosophila melanogaster
Evolution
Evolution, Molecular
Gene polymorphism
Genes
Genetic Linkage
Genetics
Genetics, Population
INDEL Mutation
Insects
Introns
Negative selection
Nucleotide sequence
Polymorphism
Polymorphism, Genetic
Selection, Genetic
Statistics, Nonparametric
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Beschreibung
Zusammenfassung:The detection of selection, both positive and negative, acting on a DNA sequence or class of nucleotide sites requires comparison with a reference sequence that is unaffected by selection. In Drosophila, recent findings of widespread selective constraint, as well as adaptive evolution, in both coding and noncoding regions highlight the difficulties in choosing such a reference sequence. Here, we investigate the utility of short intron sequences as a reference for the detection of selection. For a set of 119 Drosophila melanogaster genes containing 195 short introns (
ISSN:0737-4038
1537-1719
DOI:10.1093/molbev/msq046