General Anesthetic Actions on GABAA Receptors

General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABAA rec...

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Veröffentlicht in:Current neuropharmacology 2010-03, Vol.8 (1), p.2-9
Hauptverfasser: Garcia, Paul, Kolesky, Scott, Jenkins, Andrew
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
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Zusammenfassung:General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABAA receptor. In this review we will discuss what is known about anesthetic – GABAA receptor interactions.
ISSN:1570-159X
1875-6190
DOI:10.2174/157015910790909502