Spectrophotometric Quantitation of Metformin in Bulk Drug and Pharmaceutical Formulations using Multivariate Technique

Spectrophotometric Quantitation of Metformin in Bulk Drug and Pharmaceutical Formulations using Multivariate Technique

A sensitive and accurate UV spectrophotometric method with multivariate calibration technique for the determination of metformin hydrochloride in bulk drug and different pharmaceutical formulations has been described. This technique is based on the use of the linear regression equations by using rel...

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Veröffentlicht in:Indian journal of pharmaceutical sciences 2009-05, Vol.71 (3), p.331-335
Hauptverfasser: Arayne, M S, Sultana, Najma, Zuberi, M H, Siddiqui, F A
Format: Artikel
Sprache:eng
Schlagworte:
Accuracy
Analytical chemistry
Calibration
Measurement
Metformin
Short Communication
Spectrophotometer
Spectrum analysis
Standard deviation
Statistical methods
Studies
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Zusammenfassung:A sensitive and accurate UV spectrophotometric method with multivariate calibration technique for the determination of metformin hydrochloride in bulk drug and different pharmaceutical formulations has been described. This technique is based on the use of the linear regression equations by using relationship between concentration and absorbance at five different wavelength. The results were treated statistically and were found highly accurate, precise and reproducible. The method is accurate, precise (% recovery 102.50+/-0.063, CV
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.56022