Association of Indian Diabetes Risk Score with arterial stiffness in Asian Indian nondiabetic subjects: the Chennai Urban Rural Epidemiology Study (CURES-84)

In this study, we aim to determine the association of Indian Diabetes Risk Score (IDRS) with augmentation index (AI), a preclinical marker of early atherosclerotic changes. Subjects without known diabetes (n = 1985) were randomly selected from the Chennai Urban Rural Epidemiology Study, an ongoing population-based study on a representative population (aged >or=20 years) of Chennai, the largest city in Southern India. Augmentation index was measured using the Sphygmocor apparatus (Sphygmocor BPAS-1; PWV Medical, Sydney, Australia). Serum lipids were measured in an overnight fasting sample along with other biochemical parameters. Indian Diabetes Risk Score includes four parameters: age, abdominal obesity, family history of type 2 diabetes, and physical activity. Arterial stiffness values increased with an increase in IDRS. Subjects with IDRS >or=60 had significantly higher AI (24.6 +/- 7.2; p < .001) compared to subjects with an IDRS of 30-60 (16.4 +/- 5.5; p < .001) and with IDRS