Human frataxin: iron and ferrochelatase binding surface

Human frataxin: iron and ferrochelatase binding surface

The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein's ability to serve as the iron chaperone during heme biosynthesis.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2007-01 (18), p.1798-1800
Hauptverfasser: Bencze, Krisztina Z, Yoon, Taejin, Millán-Pacheco, César, Bradley, Patrick B, Pastor, Nina, Cowan, J A, Stemmler, Timothy L
Format: Artikel
Sprache:eng
Schlagworte:
Crystallography, X-Ray
Ferrochelatase - metabolism
Frataxin
Heme - biosynthesis
Humans
Iron - metabolism
Iron-Binding Proteins - metabolism
Magnetic Resonance Spectroscopy
Molecular Chaperones - metabolism
Surface Properties
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Beschreibung
Zusammenfassung:The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein's ability to serve as the iron chaperone during heme biosynthesis.
ISSN:1359-7345
1364-548X
DOI:10.1039/b703195e