A general electrochemical method for label-free screening of protein-small molecule interactions

Here we report a versatile method by which the interaction between a protein and a small molecule, and the disruption of that interaction by competition with other small molecules, can be monitored electrochemically directly in complex sample matrices.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2009-01 (41), p.6222-6224
Hauptverfasser:	Cash, Kevin J, Ricci, Francesco, Plaxco, Kevin W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensing Techniques - methods DNA - chemistry Electrochemistry - methods Protein Binding Protein Interaction Mapping - methods Proteins - metabolism Small Molecule Libraries - analysis Small Molecule Libraries - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Here we report a versatile method by which the interaction between a protein and a small molecule, and the disruption of that interaction by competition with other small molecules, can be monitored electrochemically directly in complex sample matrices.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b911558g