Enhanced working and verbal memory after lamotrigine treatment in pediatric bipolar disorder

Pavuluri MN, Passarotti AM, Mohammed T, Carbray JA, Sweeney JA. Enhanced working and verbal memory after lamotrigine treatment in pediatric bipolar disorder. Bipolar Disord 2010: 12: 213–220. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S. Objective: To examine the treatment impact of lamotrigine on the neurocognitive profile of patients with pediatric bipolar disorder (PBD). Method: Healthy controls (HC) (n = 24; mean age = 12.4 ± 3.3 years) and unmedicated PBD patients with manic, mixed, or hypomanic episodes (n = 34; mean age = 13 ± 3.1 years) were matched for IQ, age, sex, race, and socioeconomic status. A neurocognitive battery was administered at baseline and again after 14 weeks, during which PBD patients were treated with lamotrigine. Results: Clinical symptoms improved with treatment in the patient group with significant change from baseline to follow‐up on the Young Mania Rating Scale (p