Dipeptidyl Peptidase IV and incident Diabetes: The Atherosclerosis Risk in Communities (ARIC) study

Dipeptidyl Peptidase IV and incident Diabetes: The Atherosclerosis Risk in Communities (ARIC) study

Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes. Using a case-cohort design, we followed 546 middle-aged individuals who devel...

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Veröffentlicht in:Diabetes care 2010-05, Vol.33 (5), p.1109-1111
Hauptverfasser: LUFT, Vivian C, INES SCHMIDT, Maria, PANKOW, James S, HOOGEVEEN, Ron C, COUPER, David, HEISS, Gerardo, DUNCAN, Bruce B
Format: Artikel
Sprache:eng
Schlagworte:
African Americans
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - epidemiology
Atherosclerosis - immunology
Biological and medical sciences
Blood
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - immunology
Diabetes. Impaired glucose tolerance
Dipeptidyl Peptidase 4 - blood
Dipeptidyl Peptidase 4 - immunology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fasting
Female
Human subjects
Humans
Incidence
Inflammation - blood
Inflammation - epidemiology
Inflammation - immunology
Male
Medical sciences
Metabolic diseases
Middle Aged
Miscellaneous
Mortality
Original Research
Predictive Value of Tests
Proportional Hazards Models
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Smoking - epidemiology
Software packages
Studies
Triglycerides
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Zusammenfassung:Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes. Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over approximately 9 years within the Atherosclerosis Risk in Communities study. In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations
ISSN:0149-5992
1935-5548
DOI:10.2337/dc09-1996