Ubiquitin Proteasome Dysfunction in Human Hypertrophic and Dilated Cardiomyopathies

The ubiquitin proteasome system maintains a dynamic equilibrium of proteins and prevents accumulation of damaged and misfolded proteins, yet its role in human cardiac dysfunction is not well understood. The present study evaluated ubiquitin proteasome system function in human heart failure and hyper...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2010-03, Vol.121 (8), p.997-1004
Hauptverfasser:	PREDMORE, Jaime M, PING WANG, DAVIS, Frank, BARTOLONE, Sarah, WESTFALL, Margaret V, DYKE, David B, PAGANI, Francis, POWELL, Saul R, DAY, Sharlene M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - physiology Adolescent Adult Aged Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - physiopathology Cardiomyopathy, Hypertrophic - metabolism Cardiomyopathy, Hypertrophic - physiopathology Cardiovascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Humans Male Medical sciences Middle Aged Oxidative Stress - physiology Peptide Hydrolases - metabolism Pharmacology. Drug treatments Proteasome Endopeptidase Complex - physiology Protein Processing, Post-Translational - physiology Proto-Oncogene Proteins c-akt - metabolism Tumor Suppressor Protein p53 - metabolism Ubiquitin - physiology Vasodilator agents. Cerebral vasodilators Young Adult
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Zusammenfassung:	The ubiquitin proteasome system maintains a dynamic equilibrium of proteins and prevents accumulation of damaged and misfolded proteins, yet its role in human cardiac dysfunction is not well understood. The present study evaluated ubiquitin proteasome system function in human heart failure and hypertrophic cardiomyopathy (HCM). Proteasome function was studied in human nonfailing donor hearts, explanted failing hearts, and myectomy samples from patients with HCM. Proteasome proteolytic activities were markedly reduced in failing and HCM hearts compared with nonfailing hearts (P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/circulationaha.109.904557