ZAP-70: an essential kinase in T-cell signaling

ZAP-70: an essential kinase in T-cell signaling

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in wh...

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Veröffentlicht in:Cold Spring Harbor perspectives in biology 2010-05, Vol.2 (5), p.a002279-a002279
Hauptverfasser: Wang, Haopeng, Kadlecek, Theresa A, Au-Yeung, Byron B, Goodfellow, Hanna E Sjölin, Hsu, Lih-Yun, Freedman, Tanya S, Weiss, Arthur
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Enzyme Inhibitors - pharmacology
Humans
Mice
Models, Molecular
Phosphorylation
Protein Conformation
Receptors, Antigen, T-Cell - metabolism
Signal Transduction
T-Lymphocytes - cytology
T-Lymphocytes - enzymology
ZAP-70 Protein-Tyrosine Kinase - antagonists & inhibitors
ZAP-70 Protein-Tyrosine Kinase - chemistry
ZAP-70 Protein-Tyrosine Kinase - metabolism
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Zusammenfassung:ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a002279