Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer

AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically e...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2010-04, Vol.16 (15), p.1879-1884
Hauptverfasser:	Hermanova, Marketa, Karasek, Petr, Tomasek, Jiri, Lenz, Jiri, Jarkovsky, Jiri, Dite, Petr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal - metabolism Brief Cyclooxygenase 2 - biosynthesis Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Immunohistochemistry - methods Male Middle Aged Pancreatic Ducts - enzymology Pancreatic Ducts - pathology Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - surgery Prognosis Proportional Hazards Models
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Zusammenfassung:	AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expressi...
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v16.i15.1879