Chemokines and hepatocellular carcinoma

Chemokines and hepatocellular carcinoma

Chemokines play a paramount role in tumor progres-sion. In hepatocellular carcinoma (HCC) progression, chemokines and their receptors play an intricate role. Currently, chemokines and their receptors such as the CXCL12-CXCR4 axis, CX3CL1-CX3CR1 axis and the CCL20-CCR6 axis have received much researc...

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Veröffentlicht in:World journal of gastroenterology : WJG 2010-04, Vol.16 (15), p.1832-1836
Hauptverfasser: Huang, Fan, Geng, Xiao-Ping
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - pharmacology
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Chemokine CCL20 - metabolism
Chemokine CXCL12 - metabolism
Chemokines - metabolism
Disease Progression
Gene Expression Regulation, Neoplastic
Humans
Immune System
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Models, Biological
Neoplasm Metastasis
Receptors, CCR6 - metabolism
Receptors, CXCR4 - metabolism
Review
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Beschreibung
Zusammenfassung:Chemokines play a paramount role in tumor progres-sion. In hepatocellular carcinoma (HCC) progression, chemokines and their receptors play an intricate role. Currently, chemokines and their receptors such as the CXCL12-CXCR4 axis, CX3CL1-CX3CR1 axis and the CCL20-CCR6 axis have received much research attention. Although a large number of studies show that these axes are strongly associated with HCC, the exact mechanism by which these axes promote the growth and progression of HCC remains unknown. In this pa...
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v16.i15.1832