Effects of aging on B cell function

Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in immunology 2009-08, Vol.21 (4), p.425-430
Hauptverfasser:	Frasca, Daniela, Blomberg, Bonnie B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - immunology Aging - metabolism Aging - pathology Allergy and Immunology Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Cytidine Deaminase - genetics Cytidine Deaminase - immunology Cytidine Deaminase - metabolism Gene Expression Regulation - immunology Humans Immune Tolerance Immunoglobulin Class Switching Mice Somatic Hypermutation, Immunoglobulin TCF Transcription Factors - genetics TCF Transcription Factors - immunology TCF Transcription Factors - metabolism Transcription Factor 7-Like 1 Protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!