Effects of aging on B cell function

Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (...

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Veröffentlicht in:	Current opinion in immunology 2009-08, Vol.21 (4), p.425-430
Hauptverfasser:	Frasca, Daniela, Blomberg, Bonnie B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - immunology Aging - metabolism Aging - pathology Allergy and Immunology Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Cytidine Deaminase - genetics Cytidine Deaminase - immunology Cytidine Deaminase - metabolism Gene Expression Regulation - immunology Humans Immune Tolerance Immunoglobulin Class Switching Mice Somatic Hypermutation, Immunoglobulin TCF Transcription Factors - genetics TCF Transcription Factors - immunology TCF Transcription Factors - metabolism Transcription Factor 7-Like 1 Protein
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Beschreibung
Zusammenfassung:	Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (AID), and E47 transcription factor. Effects on somatic hypermutation (SHM) have been varied depending on the system studied. Increase of AID in mice has shown improved CSR but not SHM. The reported microarray analysis of human B cell subsets may now be used to delineate B cell defects with aging and all the advances presented should lead to selecting agents for improved immune response in the elderly.
ISSN:	0952-7915 1879-0372 1879-0372
DOI:	10.1016/j.coi.2009.06.001