The quality of life of adult survivors of childhood hematopoietic cell transplant
Survival rates after myeloablative hematopoietic cell transplantation (HCT) in childhood have improved. We conducted a cross-sectional study evaluating the quality of life (QOL) of 214 adult survivors of a childhood HCT compared with controls using standardized self-report measures with strong psych...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2010-04, Vol.45 (4), p.746-754 |
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| creator | Sanders, J E Hoffmeister, P A Storer, B E Appelbaum, F R Storb, R F Syrjala, K L |
| description | Survival rates after myeloablative hematopoietic cell transplantation (HCT) in childhood have improved. We conducted a cross-sectional study evaluating the quality of life (QOL) of 214 adult survivors of a childhood HCT compared with controls using standardized self-report measures with strong psychometric properties to evaluate physical function, psychological function and cognitive symptoms. From these results we conducted a multivariate analysis of risk factors. This analysis for physical functioning showed poorer function among myeloid disease survivors compared with patients with all other diagnoses (
P
=0.02), men functioned better than women (
P
=0.05) and those >18 years after transplant functioned more poorly than those |
| doi_str_mv | 10.1038/bmt.2009.224 |
| format | Article |
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P
=0.02), men functioned better than women (
P
=0.05) and those >18 years after transplant functioned more poorly than those <18 years after transplant (
P
=0.05). Psychological functioning showed that those who received more therapy and females were more likely to be depressed (
P
=0.03) and (
P
=0.005). Perceived cognitive symptoms showed that female survivors had more symptoms than male survivors (
P
=0.01), and those receiving more preceding therapy compared with those with less preceding therapy (
P
=0.001) or cranial irradiation compared with those without cranial irradiation (
P
=0.002) had more perceived cognitive symptoms. Overall, these data indicate that the majority of adult survivors of a childhood transplant are functioning well, but some have problems that need to be addressed.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/bmt.2009.224</identifier><identifier>PMID: 19718073</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Care and treatment ; Case-Control Studies ; Cell Biology ; Child ; Child, Preschool ; Childhood ; Children ; Cognitive ability ; Cross-Sectional Studies ; Evaluation ; Female ; Follow-Up Studies ; Graft versus host reaction ; Health aspects ; Hematology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic stem cells ; Humans ; Internal Medicine ; Irradiation ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Men ; Multivariate analysis ; Myeloid cells ; original-article ; Public Health ; Quality of Life ; Radiation ; Risk analysis ; Risk factors ; Signs and symptoms ; Skull ; Stem cell transplantation ; Stem Cells ; Survival ; Survivors ; Therapy ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplants & implants ; Young Adult</subject><ispartof>Bone marrow transplantation (Basingstoke), 2010-04, Vol.45 (4), p.746-754</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2010</rights><rights>Macmillan Publishers Limited 2010.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-9d08dd407880751af984a90f93b426583c8f16ed045b0dfdf06c009a7910148c3</citedby><cites>FETCH-LOGICAL-c702t-9d08dd407880751af984a90f93b426583c8f16ed045b0dfdf06c009a7910148c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/bmt.2009.224$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/bmt.2009.224$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22782799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19718073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanders, J E</creatorcontrib><creatorcontrib>Hoffmeister, P A</creatorcontrib><creatorcontrib>Storer, B E</creatorcontrib><creatorcontrib>Appelbaum, F R</creatorcontrib><creatorcontrib>Storb, R F</creatorcontrib><creatorcontrib>Syrjala, K L</creatorcontrib><title>The quality of life of adult survivors of childhood hematopoietic cell transplant</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>Survival rates after myeloablative hematopoietic cell transplantation (HCT) in childhood have improved. We conducted a cross-sectional study evaluating the quality of life (QOL) of 214 adult survivors of a childhood HCT compared with controls using standardized self-report measures with strong psychometric properties to evaluate physical function, psychological function and cognitive symptoms. From these results we conducted a multivariate analysis of risk factors. This analysis for physical functioning showed poorer function among myeloid disease survivors compared with patients with all other diagnoses (
P
=0.02), men functioned better than women (
P
=0.05) and those >18 years after transplant functioned more poorly than those <18 years after transplant (
P
=0.05). Psychological functioning showed that those who received more therapy and females were more likely to be depressed (
P
=0.03) and (
P
=0.005). Perceived cognitive symptoms showed that female survivors had more symptoms than male survivors (
P
=0.01), and those receiving more preceding therapy compared with those with less preceding therapy (
P
=0.001) or cranial irradiation compared with those without cranial irradiation (
P
=0.002) had more perceived cognitive symptoms. Overall, these data indicate that the majority of adult survivors of a childhood transplant are functioning well, but some have problems that need to be addressed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Cell Biology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Cross-Sectional Studies</subject><subject>Evaluation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft versus host reaction</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Irradiation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Men</subject><subject>Multivariate analysis</subject><subject>Myeloid cells</subject><subject>original-article</subject><subject>Public Health</subject><subject>Quality of Life</subject><subject>Radiation</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Signs and symptoms</subject><subject>Skull</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Survival</subject><subject>Survivors</subject><subject>Therapy</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Young Adult</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt1rFDEUxQdR7Fp981kGi_rirEkmny9CKVaFggj1OWTzsZOSmWwnmYX-92bYpdstFclDIPndk5x7T1W9hWAJQcu_rPq8RACIJUL4WbWAmNGGtJQ8rxYAUd60LRUn1auUbgCAGAPysjqBgkEOWLuofl93tr6dVPD5ro6uDt7ZeVdmCrlO07j12zim-Uh3PpguRlN3tlc5bqK32eta2xDqPKohbYIa8uvqhVMh2Tf7_bT6c_nt-uJHc_Xr-8-L86tGM4ByIwzgxmDAePkIgcoJjpUATrQrjCjhreYOUmsAJitgnHGA6uJSMQGLDa7b0-rrTnczrXprtB3KH4LcjL5X452Mysvjm8F3ch23EnECBGFF4NNeYIy3k01Z9j7NZtRg45Qkw5gighD4P9m2nAjKYSHPHpE3cRqH0geJKEZQAAZnvff_pCClFGFKDlJrFaz0g4vFhZ4flucItQLwMt5CLZ-gyjK29zoO1vlyflTw8UFBZ1XIXYphyj4O6Rj8vAP1GFMarbtvLQRyTp4syZNz8mRJXsHfPRzHAd5HrQAf9oBKWgVXAqN9uucQYhwxIQrX7LhUroa1HQ_NefLhvxKz7GI</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Sanders, J E</creator><creator>Hoffmeister, P A</creator><creator>Storer, B E</creator><creator>Appelbaum, F R</creator><creator>Storb, R F</creator><creator>Syrjala, K L</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20100401</creationdate><title>The quality of life of adult survivors of childhood hematopoietic cell transplant</title><author>Sanders, J E ; Hoffmeister, P A ; Storer, B E ; Appelbaum, F R ; Storb, R F ; Syrjala, K L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-9d08dd407880751af984a90f93b426583c8f16ed045b0dfdf06c009a7910148c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Cell Biology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Cross-Sectional Studies</topic><topic>Evaluation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft versus host reaction</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Irradiation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Men</topic><topic>Multivariate analysis</topic><topic>Myeloid cells</topic><topic>original-article</topic><topic>Public Health</topic><topic>Quality of Life</topic><topic>Radiation</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Signs and symptoms</topic><topic>Skull</topic><topic>Stem cell transplantation</topic><topic>Stem Cells</topic><topic>Survival</topic><topic>Survivors</topic><topic>Therapy</topic><topic>Transfusions. Complications. Transfusion reactions. 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We conducted a cross-sectional study evaluating the quality of life (QOL) of 214 adult survivors of a childhood HCT compared with controls using standardized self-report measures with strong psychometric properties to evaluate physical function, psychological function and cognitive symptoms. From these results we conducted a multivariate analysis of risk factors. This analysis for physical functioning showed poorer function among myeloid disease survivors compared with patients with all other diagnoses (
P
=0.02), men functioned better than women (
P
=0.05) and those >18 years after transplant functioned more poorly than those <18 years after transplant (
P
=0.05). Psychological functioning showed that those who received more therapy and females were more likely to be depressed (
P
=0.03) and (
P
=0.005). Perceived cognitive symptoms showed that female survivors had more symptoms than male survivors (
P
=0.01), and those receiving more preceding therapy compared with those with less preceding therapy (
P
=0.001) or cranial irradiation compared with those without cranial irradiation (
P
=0.002) had more perceived cognitive symptoms. Overall, these data indicate that the majority of adult survivors of a childhood transplant are functioning well, but some have problems that need to be addressed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19718073</pmid><doi>10.1038/bmt.2009.224</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2010-04, Vol.45 (4), p.746-754 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2850957 |
| source | MEDLINE; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Case-Control Studies Cell Biology Child Child, Preschool Childhood Children Cognitive ability Cross-Sectional Studies Evaluation Female Follow-Up Studies Graft versus host reaction Health aspects Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Internal Medicine Irradiation Male Medical sciences Medicine Medicine & Public Health Men Multivariate analysis Myeloid cells original-article Public Health Quality of Life Radiation Risk analysis Risk factors Signs and symptoms Skull Stem cell transplantation Stem Cells Survival Survivors Therapy Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplants & implants Young Adult |
| title | The quality of life of adult survivors of childhood hematopoietic cell transplant |
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