The quality of life of adult survivors of childhood hematopoietic cell transplant

Survival rates after myeloablative hematopoietic cell transplantation (HCT) in childhood have improved. We conducted a cross-sectional study evaluating the quality of life (QOL) of 214 adult survivors of a childhood HCT compared with controls using standardized self-report measures with strong psych...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2010-04, Vol.45 (4), p.746-754
Hauptverfasser:	Sanders, J E, Hoffmeister, P A, Storer, B E, Appelbaum, F R, Storb, R F, Syrjala, K L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Case-Control Studies Cell Biology Child Child, Preschool Childhood Children Cognitive ability Cross-Sectional Studies Evaluation Female Follow-Up Studies Graft versus host reaction Health aspects Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Internal Medicine Irradiation Male Medical sciences Medicine Medicine & Public Health Men Multivariate analysis Myeloid cells original-article Public Health Quality of Life Radiation Risk analysis Risk factors Signs and symptoms Skull Stem cell transplantation Stem Cells Survival Survivors Therapy Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplants & implants Young Adult
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Zusammenfassung:	Survival rates after myeloablative hematopoietic cell transplantation (HCT) in childhood have improved. We conducted a cross-sectional study evaluating the quality of life (QOL) of 214 adult survivors of a childhood HCT compared with controls using standardized self-report measures with strong psychometric properties to evaluate physical function, psychological function and cognitive symptoms. From these results we conducted a multivariate analysis of risk factors. This analysis for physical functioning showed poorer function among myeloid disease survivors compared with patients with all other diagnoses ( P =0.02), men functioned better than women ( P =0.05) and those >18 years after transplant functioned more poorly than those
ISSN:	0268-3369 1476-5365
DOI:	10.1038/bmt.2009.224