Wilson disease:Histopathological correlations with treatment on follow-up liver biopsies

Wilson disease:Histopathological correlations with treatment on follow-up liver biopsies

AIM:To investigate the progression of hepatic histopathology in serial liver biopsies from Wilson disease(WD)patients.METHODS:We report a group of 12 WD patients treated with zinc and/or penicillamine who underwent multiple follow-up liver biopsies.Demographic,clinical and laboratory data were gathe...

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Veröffentlicht in:World journal of gastroenterology : WJG 2010-03, Vol.16 (12), p.1487-1494
Hauptverfasser: Cope-Yokoyama, Sandy, Finegold, Milton J, Sturniolo, Giacomo Carlo, Kim, Kyoungmi, Mescoli, Claudia, Rugge, Massimo, Medici, Valentina
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Biomarkers - blood
Biopsy
Brief
Chelating Agents - therapeutic use
Child
Copper - metabolism
Copper - urine
Female
Hepatolenticular Degeneration - complications
Hepatolenticular Degeneration - drug therapy
Hepatolenticular Degeneration - metabolism
Hepatolenticular Degeneration - pathology
Humans
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver Cirrhosis - drug therapy
Liver Cirrhosis - etiology
Liver Cirrhosis - metabolism
Liver Cirrhosis - pathology
Male
Penicillamine - therapeutic use
Time Factors
Treatment Outcome
Young Adult
Zinc Sulfate - therapeutic use
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Beschreibung
Zusammenfassung:AIM:To investigate the progression of hepatic histopathology in serial liver biopsies from Wilson disease(WD)patients.METHODS:We report a group of 12 WD patients treated with zinc and/or penicillamine who underwent multiple follow-up liver biopsies.Demographic,clinical and laboratory data were gathered and all patients underwent an initial biopsy and at least one repeat biopsy.RESULTS:Time to repeat biopsy ranged from 2 to 12 years.Six patients(non-progressors)showed stable hepatic histology or improvement...
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v16.i12.1487