Schweinfurthins I and J from Macaranga schweinfurthii
Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-T...
Gespeichert in:
| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2010-03, Vol.73 (3), p.479-481 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 481 |
|---|---|
| container_issue | 3 |
| container_start_page | 479 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 73 |
| creator | Klausmeyer, Paul Van, Que N Jato, Johnson McCloud, Thomas G Beutler, John A |
| description | Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques. |
| doi_str_mv | 10.1021/np9006348 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2846236</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733813101</sourcerecordid><originalsourceid>FETCH-LOGICAL-a458t-e2998b3c01c178e1c68158af02595851e23422be5a58b58135cd8e9b6326d3203</originalsourceid><addsrcrecordid>eNpt0E9LwzAYBvAgipvTg19AexHxUH2TNFl6EWT4F8WDeg5vs3Tr6NKZrIrf3szNqeApgfx48vAQsk_hlAKjZ26WA0ieqQ3SpYJBKoGJTdIFKnnKlcw6ZCeECQBwyMU26bB4hUxkXSKezPjdVq5s_XxcuZDcJuiGyV1S-maaPKBBj26ESfjNql2yVWId7N7q7JGXq8vnwU16_3h9O7i4TzETap5alueq4AaooX1lqZGKCoVlbJcLJahlPGOssAKFKoSiXJihsnkhOZNDzoD3yPkyd9YWUzs01s091nrmqyn6D91gpf--uGqsR82bZiqTjMsYcLwK8M1ra8NcT6tgbF2js00bdJ_z-C0FGuXJUhrfhOBtuf6Fgl6srNcrR3vwu9Zafs8awdEKYDBYl3FDU4Ufx0SW99XCHS5diY3GkY_m5YnFNkDVV7OfJDRBT5rWu7j3P5U-AfS7l9Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733813101</pqid></control><display><type>article</type><title>Schweinfurthins I and J from Macaranga schweinfurthii</title><source>MEDLINE</source><source>ACS Publications</source><creator>Klausmeyer, Paul ; Van, Que N ; Jato, Johnson ; McCloud, Thomas G ; Beutler, John A</creator><creatorcontrib>Klausmeyer, Paul ; Van, Que N ; Jato, Johnson ; McCloud, Thomas G ; Beutler, John A</creatorcontrib><description>Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.</description><identifier>ISSN: 0163-3864</identifier><identifier>ISSN: 1520-6025</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np9006348</identifier><identifier>PMID: 20000454</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Northbrook, IL: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Cameroon ; Euphorbiaceae - chemistry ; General pharmacology ; Medical sciences ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Leaves - chemistry ; Plants, Medicinal - chemistry ; Stilbenes - chemistry ; Stilbenes - isolation & purification ; Stilbenes - pharmacology</subject><ispartof>Journal of natural products (Washington, D.C.), 2010-03, Vol.73 (3), p.479-481</ispartof><rights>Copyright © 2009 American Chemical Society and American Society of Pharmacognosy and American Society of Pharmacognosy</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a458t-e2998b3c01c178e1c68158af02595851e23422be5a58b58135cd8e9b6326d3203</citedby><cites>FETCH-LOGICAL-a458t-e2998b3c01c178e1c68158af02595851e23422be5a58b58135cd8e9b6326d3203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np9006348$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np9006348$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22549784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20000454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klausmeyer, Paul</creatorcontrib><creatorcontrib>Van, Que N</creatorcontrib><creatorcontrib>Jato, Johnson</creatorcontrib><creatorcontrib>McCloud, Thomas G</creatorcontrib><creatorcontrib>Beutler, John A</creatorcontrib><title>Schweinfurthins I and J from Macaranga schweinfurthii</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cameroon</subject><subject>Euphorbiaceae - chemistry</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Leaves - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Stilbenes - chemistry</subject><subject>Stilbenes - isolation & purification</subject><subject>Stilbenes - pharmacology</subject><issn>0163-3864</issn><issn>1520-6025</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E9LwzAYBvAgipvTg19AexHxUH2TNFl6EWT4F8WDeg5vs3Tr6NKZrIrf3szNqeApgfx48vAQsk_hlAKjZ26WA0ieqQ3SpYJBKoGJTdIFKnnKlcw6ZCeECQBwyMU26bB4hUxkXSKezPjdVq5s_XxcuZDcJuiGyV1S-maaPKBBj26ESfjNql2yVWId7N7q7JGXq8vnwU16_3h9O7i4TzETap5alueq4AaooX1lqZGKCoVlbJcLJahlPGOssAKFKoSiXJihsnkhOZNDzoD3yPkyd9YWUzs01s091nrmqyn6D91gpf--uGqsR82bZiqTjMsYcLwK8M1ra8NcT6tgbF2js00bdJ_z-C0FGuXJUhrfhOBtuf6Fgl6srNcrR3vwu9Zafs8awdEKYDBYl3FDU4Ufx0SW99XCHS5diY3GkY_m5YnFNkDVV7OfJDRBT5rWu7j3P5U-AfS7l9Y</recordid><startdate>20100326</startdate><enddate>20100326</enddate><creator>Klausmeyer, Paul</creator><creator>Van, Que N</creator><creator>Jato, Johnson</creator><creator>McCloud, Thomas G</creator><creator>Beutler, John A</creator><general>American Chemical Society and American Society of Pharmacognosy</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100326</creationdate><title>Schweinfurthins I and J from Macaranga schweinfurthii</title><author>Klausmeyer, Paul ; Van, Que N ; Jato, Johnson ; McCloud, Thomas G ; Beutler, John A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a458t-e2998b3c01c178e1c68158af02595851e23422be5a58b58135cd8e9b6326d3203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cameroon</topic><topic>Euphorbiaceae - chemistry</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Leaves - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Stilbenes - chemistry</topic><topic>Stilbenes - isolation & purification</topic><topic>Stilbenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klausmeyer, Paul</creatorcontrib><creatorcontrib>Van, Que N</creatorcontrib><creatorcontrib>Jato, Johnson</creatorcontrib><creatorcontrib>McCloud, Thomas G</creatorcontrib><creatorcontrib>Beutler, John A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klausmeyer, Paul</au><au>Van, Que N</au><au>Jato, Johnson</au><au>McCloud, Thomas G</au><au>Beutler, John A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schweinfurthins I and J from Macaranga schweinfurthii</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2010-03-26</date><risdate>2010</risdate><volume>73</volume><issue>3</issue><spage>479</spage><epage>481</epage><pages>479-481</pages><issn>0163-3864</issn><issn>1520-6025</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.</abstract><cop>Northbrook, IL</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>20000454</pmid><doi>10.1021/np9006348</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2010-03, Vol.73 (3), p.479-481 |
| issn | 0163-3864 1520-6025 1520-6025 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2846236 |
| source | MEDLINE; ACS Publications |
| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cameroon Euphorbiaceae - chemistry General pharmacology Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry Stilbenes - chemistry Stilbenes - isolation & purification Stilbenes - pharmacology |
| title | Schweinfurthins I and J from Macaranga schweinfurthii |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A49%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Schweinfurthins%20I%20and%20J%20from%20Macaranga%20schweinfurthii&rft.jtitle=Journal%20of%20natural%20products%20(Washington,%20D.C.)&rft.au=Klausmeyer,%20Paul&rft.date=2010-03-26&rft.volume=73&rft.issue=3&rft.spage=479&rft.epage=481&rft.pages=479-481&rft.issn=0163-3864&rft.eissn=1520-6025&rft.coden=JNPRDF&rft_id=info:doi/10.1021/np9006348&rft_dat=%3Cproquest_pubme%3E733813101%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733813101&rft_id=info:pmid/20000454&rfr_iscdi=true |