Schweinfurthins I and J from Macaranga schweinfurthii

Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-T...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2010-03, Vol.73 (3), p.479-481
Hauptverfasser:	Klausmeyer, Paul, Van, Que N, Jato, Johnson, McCloud, Thomas G, Beutler, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cameroon Euphorbiaceae - chemistry General pharmacology Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plants, Medicinal - chemistry Stilbenes - chemistry Stilbenes - isolation & purification Stilbenes - pharmacology
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Zusammenfassung:	Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.
ISSN:	0163-3864 1520-6025 1520-6025
DOI:	10.1021/np9006348