Aberrant Fatty Acid-Binding Protein-7 Gene Expression in Cutaneous Malignant Melanoma

Fatty acid-binding protein-7 (FABP7) has been shown to be expressed in cutaneous melanoma; however, its role in tumor progression is unclear. Expression of FABP7 was assessed during melanoma progression through assessment of various clinicopathology stages of primary tumor progression and metastasis...

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Veröffentlicht in:	Journal of investigative dermatology 2010-01, Vol.130 (1), p.221-229
Hauptverfasser:	Goto, Yasufumi, Koyanagi, Kazuo, Narita, Norihiko, Kawakami, Yutaka, Takata, Minoru, Uchiyama, Aya, Nguyen, Linhda, Nguyen, Tung, Ye, Xing, Morton, Donald L., Hoon, Dave S.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carrier Proteins - genetics Cell Line, Tumor Chromosomes, Human, Pair 6 Dermatology Disease Progression Disease-Free Survival Fatty Acid-Binding Protein 7 Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Loss of Heterozygosity Medical sciences Melanoma - genetics Melanoma - mortality Melanoma - secondary Microsatellite Repeats Multivariate Analysis Neoplastic Cells, Circulating Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Skin Neoplasms - genetics Skin Neoplasms - mortality Skin Neoplasms - pathology Tumor Suppressor Proteins - genetics Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:	Fatty acid-binding protein-7 (FABP7) has been shown to be expressed in cutaneous melanoma; however, its role in tumor progression is unclear. Expression of FABP7 was assessed during melanoma progression through assessment of various clinicopathology stages of primary tumor progression and metastasis. FABP7 mRNA was highly expressed in 60 of 87 (69%) primary melanomas, compared with significant (P
ISSN:	0022-202X 1523-1747
DOI:	10.1038/jid.2009.195