Acetylcholinesterase activity in the brain of alloxan diabetic albino rats: Presence of an inhibitor of this enzyme activity in the cerebral extract

Acetylcholinesterase activity in the brain of alloxan diabetic albino rats: Presence of an inhibitor of this enzyme activity in the cerebral extract

Ischemic manifestations and cerebral dysfunction have been demonstrated in diabetes. However, the pathogenesis of diabetes-induced cerebral dysfunction still remains to be elucidated. Hence, the present study was initiated. Type-2 diabetes was induced in albino rats (280-300g) with alloxan monohydra...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of diabetes in developing countries 2009-10, Vol.29 (4), p.174-177
Hauptverfasser: Ahmed, Nayeemunnisa, Tarannum, Suraiya
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Diabetes
Diabetic neuropathy
Original
Rodents
Studies
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 177
container_issue 4
container_start_page 174
container_title International journal of diabetes in developing countries
container_volume 29
creator Ahmed, Nayeemunnisa
Tarannum, Suraiya
description Ischemic manifestations and cerebral dysfunction have been demonstrated in diabetes. However, the pathogenesis of diabetes-induced cerebral dysfunction still remains to be elucidated. Hence, the present study was initiated. Type-2 diabetes was induced in albino rats (280-300g) with alloxan monohydrate (40 mg/Kg i.v.,) and the cerebrum, cerebellum and medulla oblongata of the brain were used 48 h after alloxan injection for modulations in acetylcholinesterase (AChE, EC 3.1.1.7) activity. AChE activity in the discrete regions of the brain of rats decreased significantly (P
doi_str_mv 10.4103/0973-3930.57350
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2839133</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733810022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-4acbe89712ab1d92d5e54e5da145ca5807ddd71c984892a968e544388fa7cf903</originalsourceid><addsrcrecordid>eNplkU1vFSEUhonR2Gt17c4QN66mBQ7cARcmTeNX0kQXuiYMc8ahmQsVuE2vv8MfLLetN36s-Hif8x4OLyHPOTuRnMEpMz10YICdqB4Ue0BW3BjdgQbxkKwO6hF5UsolY0qJNTwmR4IBrAXjK_LzzGPdLX5OS4hYKmZXkDpfw3WoOxoirTPSIbu2SxN1y5JuXKRjcAPW4NvFEGKi2dXymn7OWDB6vCVjK57DEGrK-3OdQ6EYf-w2_9t7zNhaLBRvam7iU_JockvBZ_frMfn67u2X8w_dxaf3H8_PLjovuamddH5AbXou3MBHI0aFSqIaHZfKO6VZP45jz73RUhvhzFo3XYLWk-v9ZBgckzd3vlfbYYOjx9jaL_Yqh43LO5tcsH8rMcz2W7q2QoPhAM3g1b1BTt-37fvsJhSPy-Iipm2xPYDmjAnRyJf_kJdpm2Obzuq1NFJrJht0egf5nErJOB2ewpnd5233idp9ovY271bx4s8JDvzvgOEX4empEQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>864948804</pqid></control><display><type>article</type><title>Acetylcholinesterase activity in the brain of alloxan diabetic albino rats: Presence of an inhibitor of this enzyme activity in the cerebral extract</title><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Ahmed, Nayeemunnisa ; Tarannum, Suraiya</creator><creatorcontrib>Ahmed, Nayeemunnisa ; Tarannum, Suraiya</creatorcontrib><description>Ischemic manifestations and cerebral dysfunction have been demonstrated in diabetes. However, the pathogenesis of diabetes-induced cerebral dysfunction still remains to be elucidated. Hence, the present study was initiated. Type-2 diabetes was induced in albino rats (280-300g) with alloxan monohydrate (40 mg/Kg i.v.,) and the cerebrum, cerebellum and medulla oblongata of the brain were used 48 h after alloxan injection for modulations in acetylcholinesterase (AChE, EC 3.1.1.7) activity. AChE activity in the discrete regions of the brain of rats decreased significantly (P&lt;0.01, 0.05 and 0.05 respectively) in diabetes. In vitro studies using cerebral extract from alloxan diabetic rats demonstrated significant (P&lt;0.05) inhibition of AChE activity in the brain of normal animals. Feeding with Cichorium intybus (chicory) leaf extract (500 mg/Kg) for 10 days resulted in an increase in AChE activity. The impairment in the glycemic control is the basic mechanism causing inhibition of neuronal activity. Cerebral extract from alloxan diabetic rats significantly inhibited the brain AChE activity of normal animals, indicating the presence of an inhibiting factor in the cerebrum of diabetic rats. Cichorium intybus when fed for 10 days offered neuroprotection by stimulating AChE activity.</description><identifier>ISSN: 0973-3930</identifier><identifier>EISSN: 1998-3832</identifier><identifier>DOI: 10.4103/0973-3930.57350</identifier><identifier>PMID: 20336201</identifier><language>eng</language><publisher>India: Springer Nature B.V</publisher><subject>Animals ; Diabetes ; Diabetic neuropathy ; Original ; Rodents ; Studies</subject><ispartof>International journal of diabetes in developing countries, 2009-10, Vol.29 (4), p.174-177</ispartof><rights>Copyright Medknow Publications &amp; Media Pvt Ltd Oct 2009</rights><rights>International Journal of Diabetes in Developing Countries 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-4acbe89712ab1d92d5e54e5da145ca5807ddd71c984892a968e544388fa7cf903</citedby><cites>FETCH-LOGICAL-c419t-4acbe89712ab1d92d5e54e5da145ca5807ddd71c984892a968e544388fa7cf903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839133/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839133/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20336201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Nayeemunnisa</creatorcontrib><creatorcontrib>Tarannum, Suraiya</creatorcontrib><title>Acetylcholinesterase activity in the brain of alloxan diabetic albino rats: Presence of an inhibitor of this enzyme activity in the cerebral extract</title><title>International journal of diabetes in developing countries</title><addtitle>Int J Diabetes Dev Ctries</addtitle><description>Ischemic manifestations and cerebral dysfunction have been demonstrated in diabetes. However, the pathogenesis of diabetes-induced cerebral dysfunction still remains to be elucidated. Hence, the present study was initiated. Type-2 diabetes was induced in albino rats (280-300g) with alloxan monohydrate (40 mg/Kg i.v.,) and the cerebrum, cerebellum and medulla oblongata of the brain were used 48 h after alloxan injection for modulations in acetylcholinesterase (AChE, EC 3.1.1.7) activity. AChE activity in the discrete regions of the brain of rats decreased significantly (P&lt;0.01, 0.05 and 0.05 respectively) in diabetes. In vitro studies using cerebral extract from alloxan diabetic rats demonstrated significant (P&lt;0.05) inhibition of AChE activity in the brain of normal animals. Feeding with Cichorium intybus (chicory) leaf extract (500 mg/Kg) for 10 days resulted in an increase in AChE activity. The impairment in the glycemic control is the basic mechanism causing inhibition of neuronal activity. Cerebral extract from alloxan diabetic rats significantly inhibited the brain AChE activity of normal animals, indicating the presence of an inhibiting factor in the cerebrum of diabetic rats. Cichorium intybus when fed for 10 days offered neuroprotection by stimulating AChE activity.</description><subject>Animals</subject><subject>Diabetes</subject><subject>Diabetic neuropathy</subject><subject>Original</subject><subject>Rodents</subject><subject>Studies</subject><issn>0973-3930</issn><issn>1998-3832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplkU1vFSEUhonR2Gt17c4QN66mBQ7cARcmTeNX0kQXuiYMc8ahmQsVuE2vv8MfLLetN36s-Hif8x4OLyHPOTuRnMEpMz10YICdqB4Ue0BW3BjdgQbxkKwO6hF5UsolY0qJNTwmR4IBrAXjK_LzzGPdLX5OS4hYKmZXkDpfw3WoOxoirTPSIbu2SxN1y5JuXKRjcAPW4NvFEGKi2dXymn7OWDB6vCVjK57DEGrK-3OdQ6EYf-w2_9t7zNhaLBRvam7iU_JockvBZ_frMfn67u2X8w_dxaf3H8_PLjovuamddH5AbXou3MBHI0aFSqIaHZfKO6VZP45jz73RUhvhzFo3XYLWk-v9ZBgckzd3vlfbYYOjx9jaL_Yqh43LO5tcsH8rMcz2W7q2QoPhAM3g1b1BTt-37fvsJhSPy-Iipm2xPYDmjAnRyJf_kJdpm2Obzuq1NFJrJht0egf5nErJOB2ewpnd5233idp9ovY271bx4s8JDvzvgOEX4empEQ</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Ahmed, Nayeemunnisa</creator><creator>Tarannum, Suraiya</creator><general>Springer Nature B.V</general><general>Medknow Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04T</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091001</creationdate><title>Acetylcholinesterase activity in the brain of alloxan diabetic albino rats: Presence of an inhibitor of this enzyme activity in the cerebral extract</title><author>Ahmed, Nayeemunnisa ; Tarannum, Suraiya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-4acbe89712ab1d92d5e54e5da145ca5807ddd71c984892a968e544388fa7cf903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Diabetes</topic><topic>Diabetic neuropathy</topic><topic>Original</topic><topic>Rodents</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Nayeemunnisa</creatorcontrib><creatorcontrib>Tarannum, Suraiya</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Health &amp; Medicine</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of diabetes in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Nayeemunnisa</au><au>Tarannum, Suraiya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acetylcholinesterase activity in the brain of alloxan diabetic albino rats: Presence of an inhibitor of this enzyme activity in the cerebral extract</atitle><jtitle>International journal of diabetes in developing countries</jtitle><addtitle>Int J Diabetes Dev Ctries</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>29</volume><issue>4</issue><spage>174</spage><epage>177</epage><pages>174-177</pages><issn>0973-3930</issn><eissn>1998-3832</eissn><abstract>Ischemic manifestations and cerebral dysfunction have been demonstrated in diabetes. However, the pathogenesis of diabetes-induced cerebral dysfunction still remains to be elucidated. Hence, the present study was initiated. Type-2 diabetes was induced in albino rats (280-300g) with alloxan monohydrate (40 mg/Kg i.v.,) and the cerebrum, cerebellum and medulla oblongata of the brain were used 48 h after alloxan injection for modulations in acetylcholinesterase (AChE, EC 3.1.1.7) activity. AChE activity in the discrete regions of the brain of rats decreased significantly (P&lt;0.01, 0.05 and 0.05 respectively) in diabetes. In vitro studies using cerebral extract from alloxan diabetic rats demonstrated significant (P&lt;0.05) inhibition of AChE activity in the brain of normal animals. Feeding with Cichorium intybus (chicory) leaf extract (500 mg/Kg) for 10 days resulted in an increase in AChE activity. The impairment in the glycemic control is the basic mechanism causing inhibition of neuronal activity. Cerebral extract from alloxan diabetic rats significantly inhibited the brain AChE activity of normal animals, indicating the presence of an inhibiting factor in the cerebrum of diabetic rats. Cichorium intybus when fed for 10 days offered neuroprotection by stimulating AChE activity.</abstract><cop>India</cop><pub>Springer Nature B.V</pub><pmid>20336201</pmid><doi>10.4103/0973-3930.57350</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0973-3930
ispartof International journal of diabetes in developing countries, 2009-10, Vol.29 (4), p.174-177
issn 0973-3930
1998-3832
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2839133
source PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Animals
Diabetes
Diabetic neuropathy
Original
Rodents
Studies
title Acetylcholinesterase activity in the brain of alloxan diabetic albino rats: Presence of an inhibitor of this enzyme activity in the cerebral extract
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T00%3A03%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acetylcholinesterase%20activity%20in%20the%20brain%20of%20alloxan%20diabetic%20albino%20rats:%20Presence%20of%20an%20inhibitor%20of%20this%20enzyme%20activity%20in%20the%20cerebral%20extract&rft.jtitle=International%20journal%20of%20diabetes%20in%20developing%20countries&rft.au=Ahmed,%20Nayeemunnisa&rft.date=2009-10-01&rft.volume=29&rft.issue=4&rft.spage=174&rft.epage=177&rft.pages=174-177&rft.issn=0973-3930&rft.eissn=1998-3832&rft_id=info:doi/10.4103/0973-3930.57350&rft_dat=%3Cproquest_pubme%3E733810022%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=864948804&rft_id=info:pmid/20336201&rfr_iscdi=true