Acetylcholinesterase activity in the brain of alloxan diabetic albino rats: Presence of an inhibitor of this enzyme activity in the cerebral extract

Ischemic manifestations and cerebral dysfunction have been demonstrated in diabetes. However, the pathogenesis of diabetes-induced cerebral dysfunction still remains to be elucidated. Hence, the present study was initiated. Type-2 diabetes was induced in albino rats (280-300g) with alloxan monohydrate (40 mg/Kg i.v.,) and the cerebrum, cerebellum and medulla oblongata of the brain were used 48 h after alloxan injection for modulations in acetylcholinesterase (AChE, EC 3.1.1.7) activity. AChE activity in the discrete regions of the brain of rats decreased significantly (P