Development of Insulin-Sensitivity by Mouse Mammary Gland in vitro

Development of Insulin-Sensitivity by Mouse Mammary Gland in vitro

Explants from mammary gland of pregnant mice are sensitive to insulin, but corresponding explants from mature, virgin mice are insensitive to insulin in certain respects. Isolated virgin tissue can acquire insulin-sensitivity independent of exogenous insulin. Some endocrinological and developmental...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1970-11, Vol.67 (3), p.1493-1500
Hauptverfasser: Friedberg, S. H., Oka, Takami, Topper, Yale J.
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Aminoisobutyric Acids - metabolism
Animals
Biological Sciences: Biochemistry
Body tissues
Carbon Isotopes
Cattle
Culture Techniques
Cultured cells
Dehydrogenases
Developmental biology
Epithelial cells
Female
Hormones
Insulin
Insulin - pharmacology
Mammary glands
Mammary Glands, Animal - drug effects
Mice
Pregnancy
Pregnancy, Animal
Time Factors
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Zusammenfassung:Explants from mammary gland of pregnant mice are sensitive to insulin, but corresponding explants from mature, virgin mice are insensitive to insulin in certain respects. Isolated virgin tissue can acquire insulin-sensitivity independent of exogenous insulin. Some endocrinological and developmental implications are discussed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.67.3.1493