Perceptual and Neural Pliability of Odor Objects

A key function of the sense of smell is to guide organisms towards rewards and away from dangers. However, because relatively few volatile chemicals in the environment carry intrinsic biological value, the meaning of an odor often needs to be acquired through learning and experience. The tremendous perceptual and neural plasticity of the olfactory system provides a design that is ideal for the establishment of links between odor cues and behaviorally relevant events, promoting appropriate adaptive responses to foods, friends, foes, and mates. This article describes recent human neuroimaging data showing the dynamic effects of olfactory perceptual learning and aversive conditioning on the behavioral discrimination of odor objects, with parallel plasticity and reorganization in the posterior piriform and orbitofrontal cortices. The findings presented here highlight the important role of experience in shaping odor object perception and in ensuring the human sense of smell achieves its full perceptual potential.