Membrane Structure: Lipid-Protein Interactions in Microsomal Membranes

The relationships of phospholipid to membrane structure and function were examined in hepatic microsomes. Findings indicate that normal microsomal membrane structure is dependent on lipid-protein interactions and that it correlates closely with glucose-6-phosphatase activity. Modification of most ph...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1970-06, Vol.66 (2), p.433-440
Hauptverfasser:	Trump, Benjamin F., Duttera, Sue M., Byrne, William L., Arstila, Antti U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological Sciences: Biochemistry Densitometry Diglycerides Electron micrographs Glucose-6-Phosphatase - metabolism Lipids Magnification Male Membrane structures Membranes - drug effects Membranes - metabolism Membranes - physiology Microscopy, Electron Microsomes Microsomes, Liver - enzymology Microsomes, Liver - metabolism Microsomes, Liver - physiology P branes Phospholipases - pharmacology Phospholipids Phospholipids - metabolism Rats String theory
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Beschreibung
Zusammenfassung:	The relationships of phospholipid to membrane structure and function were examined in hepatic microsomes. Findings indicate that normal microsomal membrane structure is dependent on lipid-protein interactions and that it correlates closely with glucose-6-phosphatase activity. Modification of most phospholipid with phospholipase-C is associated with widening of the membrane which can be reversed following readdition of phospholipid.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.66.2.433