Antineoplastic Agents. 454. Synthesis of the Strong Cancer Cell Growth Inhibitors trans-Dihydronarciclasine and 7-Deoxy-trans-dihydronarciclasine

To further pursue the antineoplastic leads offered by our isolation of trans-dihydronarciclasine (1a) and 7-deoxy-trans-dihydronarciclasine (1c) from two medicinal plant species of the Amaryllidaceae family, a practical palladium-catalyzed hydrogenation procedure was developed for the synthesis of t...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2009-07, Vol.72 (7), p.1279-1282
Hauptverfasser:	Pettit, George R, Ducki, Sylvie, Eastham, Stephen A, Melody, Noeleen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Alkaloids - chemistry Alkaloids - pharmacology Amaryllidaceae Alkaloids Antineoplastic Agents, Phytogenic - chemical synthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Catalysis Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - pharmacology Molecular Structure Narcissus - chemistry Palladium - chemistry Phenanthridines Plants, Medicinal - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	To further pursue the antineoplastic leads offered by our isolation of trans-dihydronarciclasine (1a) and 7-deoxy-trans-dihydronarciclasine (1c) from two medicinal plant species of the Amaryllidaceae family, a practical palladium-catalyzed hydrogenation procedure was developed for the synthesis of these isocarbostyrils from narciclasine (2a) and 7-deoxynarciclasine (2c).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9001948