HYPOGLYCEMIC EFFECT OF TRECULIA AFRICANA DECNE ROOT BARK IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS

The solvent partitioned purified fractions of the hydro-acetone root bark extract of the African breadfruit ( Treculia africana Decne) were evaluated for hypoglycemic activities in normal and diabetic albino rats. Fasting blood glucose levels were estimated by the use of a glucometer at pre-determined intervals after oral administration of the test extracts/fractions. Results revealed that the test fractions have only a slight effect on blood sugar level of normal rats. On short term and chronic administration in diabetic rats however, diethyl ether-soluble (DEF) and the water-soluble (WSF) fractions significantly reduced the fasting blood sugar levels (p