Bilateral Deep Brain Stimulation vs Best Medical Therapy for Patients With Advanced Parkinson Disease: A Randomized Controlled Trial

CONTEXT Deep brain stimulation is an accepted treatment for advanced Parkinson disease (PD), although there are few randomized trials comparing treatments, and most studies exclude older patients. OBJECTIVE To compare 6-month outcomes for patients with PD who received deep brain stimulation or best...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2009-01, Vol.301 (1), p.63-73
Hauptverfasser:	Weaver, Frances M, Follett, Kenneth, Stern, Matthew, Hur, Kwan, Harris, Crystal, Marks, William J, Rothlind, Johannes, Sagher, Oren, Reda, Domenic, Moy, Claudia S, Pahwa, Rajesh, Burchiel, Kim, Hogarth, Penelope, Lai, Eugene C, Duda, John E, Holloway, Kathryn, Samii, Ali, Horn, Stacy, Bronstein, Jeff, Stoner, Gatana, Heemskerk, Jill, Huang, Grant D, CSP 468 Study Group, for the
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Brain Clinical outcomes Clinical trials Cognition Deep Brain Stimulation - adverse effects Female Globus Pallidus Humans Male Middle Aged Motor Skills Older people Original Contribution Parkinson Disease - therapy Parkinson's disease Quality of Life Subthalamic Nucleus Therapy
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Zusammenfassung:	CONTEXT Deep brain stimulation is an accepted treatment for advanced Parkinson disease (PD), although there are few randomized trials comparing treatments, and most studies exclude older patients. OBJECTIVE To compare 6-month outcomes for patients with PD who received deep brain stimulation or best medical therapy. DESIGN, SETTING, AND PATIENTS Randomized controlled trial of patients who received either deep brain stimulation or best medical therapy, stratified by study site and patient age (
ISSN:	0098-7484 1538-3598
DOI:	10.1001/jama.2008.929