Nanotubes Functionalized with Lipids and Natural Amino Acid Dendrimers: A New Strategy to Create Nanomaterials for Delivering Systemic RNAi

Single-walled carbon nanotubes (SWNT) have unique electronic, mechanical, and structural properties as well as chemical stability that make them ideal nanomaterials for applications in materials science and medicine. Here, we report the design and creation of a novel strategy for functionalizing SWN...

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Veröffentlicht in:	Bioconjugate chemistry 2010-01, Vol.21 (1), p.56-63
Hauptverfasser:	McCarroll, Joshua, Baigude, Huricha, Yang, Chao-Shun, Rana, Tariq M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - chemistry Animals Apolipoproteins B - blood Apolipoproteins B - genetics Apolipoproteins B - metabolism Biochemistry Cholesterol - blood Cholesterol - genetics Cholesterol - metabolism Dendrimers - chemistry Drug Delivery Systems - methods Lipids Lipids - chemistry Liver Liver - metabolism Liver - pathology Mice Nanotubes Nanotubes, Carbon - chemistry Ribonucleic acid RNA RNA Interference - physiology RNA, Small Interfering - administration & dosage RNA, Small Interfering - blood RNA, Small Interfering - therapeutic use Rodents Time Factors
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Beschreibung
Zusammenfassung:	Single-walled carbon nanotubes (SWNT) have unique electronic, mechanical, and structural properties as well as chemical stability that make them ideal nanomaterials for applications in materials science and medicine. Here, we report the design and creation of a novel strategy for functionalizing SWNT to systemically silence a target gene in mice by delivering siRNA at doses of
ISSN:	1043-1802 1520-4812
DOI:	10.1021/bc900296z