Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells

G protein-coupled receptors (GPCRs) mediate responses to external stimuli in various cell types. Early events, such as the binding of ligand and G proteins to the receptor, nucleotide exchange (NX), and GTPase activity at the Galpha subunit, are common for many different GPCRs. For G(q)-coupled M(1)...

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Veröffentlicht in:The Journal of general physiology 2010-02, Vol.135 (2), p.81-97
Hauptverfasser: Falkenburger, Björn H, Jensen, Jill B, Hille, Bertil
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Sprache:eng
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