A siderophore production mutant of Bordetella bronchiseptica cannot use lactoferrin as an iron source

A siderophore production mutant of Bordetella bronchiseptica cannot use lactoferrin as an iron source

Bordetella bronchiseptica secreted a hydroxamate siderophore when grown in Fe-depleted medium. A Tn5lac insertion mutant of B. bronchiseptica, DBB22, did not produce this hydroxamate siderophore and was incapable of using lactoferrin as an Fe source. Our data suggest that B. bronchiseptica uses a si...

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Veröffentlicht in:Infection and Immunity 1993-06, Vol.61 (6), p.2698-2702
Hauptverfasser: Foster, L.A.A, Dyer, D.W
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bacteriology
Biological and medical sciences
Blotting, Southern
BORDETELLA BRONCHISEPTICA
Bordetella bronchiseptica - growth & development
Bordetella bronchiseptica - metabolism
Cattle
Fundamental and applied biological sciences. Psychology
Humans
Iron - metabolism
Lactoferrin - metabolism
LACTOFERRINAS
LACTOFERRINE
Microbiology
Morphology, structure, chemical composition
Mutation
SIDEROFOROS
SIDEROPHORE
Siderophores - biosynthesis
Siderophores - genetics
Transferrin - metabolism
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Zusammenfassung:Bordetella bronchiseptica secreted a hydroxamate siderophore when grown in Fe-depleted medium. A Tn5lac insertion mutant of B. bronchiseptica, DBB22, did not produce this hydroxamate siderophore and was incapable of using lactoferrin as an Fe source. Our data suggest that B. bronchiseptica uses a siderophore for removal of Fe from lactoferrin and transferrin rather than relying upon a receptor for these host Fe-binding proteins
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.61.6.2698-2702.1993