S100A4 and Metastasis: A Small Actor Playing Many Roles

The calcium-binding protein S100A4 promotes metastasis in several experimental animal models, and S100A4 protein expression is associated with patient outcome in a number of tumor types. S100A4 is localized in the nucleus, cytoplasm, and extracellular space and possesses a wide range of biological f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of pathology 2010-02, Vol.176 (2), p.528-535
Hauptverfasser:	Boye, Kjetil, Maelandsmo, Gunhild M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Progression Humans Models, Biological Molecular Weight Neoplasm Metastasis - diagnosis Neoplasm Metastasis - genetics Prognosis Protein Binding Review S100 Calcium-Binding Protein A4 S100 Proteins - chemistry S100 Proteins - genetics S100 Proteins - metabolism S100 Proteins - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The calcium-binding protein S100A4 promotes metastasis in several experimental animal models, and S100A4 protein expression is associated with patient outcome in a number of tumor types. S100A4 is localized in the nucleus, cytoplasm, and extracellular space and possesses a wide range of biological functions, such as regulation of angiogenesis, cell survival, motility, and invasion. In this review, we summarize the evidence connecting S100A4 and cancer metastasis and discuss the mechanisms by which S100A4 promotes tumor progression.
ISSN:	0002-9440 1525-2191
DOI:	10.2353/ajpath.2010.090526