Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer

AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.METHODS: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homol...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2010-01, Vol.16 (3), p.330-338
Hauptverfasser:	Hiraki, Masatsugu, Kitajima, Yoshihiko, Sato, Seiji, Nakamura, Jun, Hashiguchi, Kazuyoshi, Noshiro, Hirokazu, Miyazaki, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Ascitic Fluid - metabolism Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cadherins - genetics Cadherins - metabolism Carcinoembryonic Antigen - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism DNA Methylation Female Gastric Mucosa - pathology Humans Keratin-19 - metabolism Male Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Neoplasm Invasiveness - pathology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - secondary Original Peritoneal Neoplasms - epidemiology Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - secondary Poly-ADP-Ribose Binding Proteins Predictive Value of Tests Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Retrospective Studies Risk Factors Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Ubiquitin-Protein Ligases
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Zusammenfassung:	AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.METHODS: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homolog 1), ABCG2 (ATP-binding cassette, sub-family G, member 2) and BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) were analyzed in 80 specimens of PF by quantitative methylation-specific polymerase chain r...
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v16.i3.330