Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis
AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and use...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2010-01, Vol.16 (2), p.217-224 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Gehling, Ursula M Willems, Marc Schlagner, Kathleen Benndorf, Ralf A Dandri, Maura Petersen, Jörg Sterneck, Martina Pollok, Joerg-Matthias Hossfeld, Dieter K Rogiers, Xavier |
| description | AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype we... |
| doi_str_mv | 10.3748/wjg.v16.i2.217 |
| format | Article |
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METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype we...</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v16.i2.217</identifier><identifier>PMID: 20066741</identifier><language>eng</language><publisher>United States: Department of Hepatobiliary Surgery and Transplant Surgery,University Hospital HamburgEppendorf,20246 Hamburg,Germany%Department of Medicine,University Hospital Hamburg-Eppendorf,20246 Hamburg,Germany%Institute of Experimental and Clinical Pharmacology and Toxicology,University Hospital HamburgEppendorf,20246 Hamburg,Germany%Department of Hepatobiliary Surgery and Transplant Surgery,University Hospital HamburgEppendorf,20246 Hamburg,Germany</publisher><subject>AC133 Antigen ; Adult ; Antigens, CD - metabolism ; Brief ; Cell Movement - physiology ; Chemokine CXCL12 - metabolism ; Female ; Glycoproteins - metabolism ; Hematopoietic Stem Cells - metabolism ; Hematopoietic Stem Cells - pathology ; Hematopoietic Stem Cells - physiology ; Humans ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - pathology ; Liver Cirrhosis - physiopathology ; Male ; Membrane Proteins - metabolism ; Middle Aged ; Peptides - metabolism ; Proto-Oncogene Proteins c-kit - metabolism ; Receptors, CXCR4 - metabolism ; Young Adult</subject><ispartof>World journal of gastroenterology : WJG, 2010-01, Vol.16 (2), p.217-224</ispartof><rights>Copyright © Wanfang Data Co. 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METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. 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| issn | 1007-9327 2219-2840 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | AC133 Antigen Adult Antigens, CD - metabolism Brief Cell Movement - physiology Chemokine CXCL12 - metabolism Female Glycoproteins - metabolism Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Hematopoietic Stem Cells - physiology Humans Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Cirrhosis - physiopathology Male Membrane Proteins - metabolism Middle Aged Peptides - metabolism Proto-Oncogene Proteins c-kit - metabolism Receptors, CXCR4 - metabolism Young Adult |
| title | Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis |
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