Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis

AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and use...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2010-01, Vol.16 (2), p.217-224
Hauptverfasser:	Gehling, Ursula M, Willems, Marc, Schlagner, Kathleen, Benndorf, Ralf A, Dandri, Maura, Petersen, Jörg, Sterneck, Martina, Pollok, Joerg-Matthias, Hossfeld, Dieter K, Rogiers, Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Adult Antigens, CD - metabolism Brief Cell Movement - physiology Chemokine CXCL12 - metabolism Female Glycoproteins - metabolism Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Hematopoietic Stem Cells - physiology Humans Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Cirrhosis - physiopathology Male Membrane Proteins - metabolism Middle Aged Peptides - metabolism Proto-Oncogene Proteins c-kit - metabolism Receptors, CXCR4 - metabolism Young Adult
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Zusammenfassung:	AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype we...
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v16.i2.217