P66Shc signals to age

P66Shc signals to age

Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and long...

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Veröffentlicht in:Aging (Albany, NY.) NY.), 2009-06, Vol.1 (6), p.503-510
Hauptverfasser: Trinei, Mirella, Berniakovich, Ina, Beltrami, Elena, Migliaccio, Enrica, Fassina, Ambrogio, Pelicci, PierGiuseppe, Giorgio, Marco
Format: Artikel
Sprache:eng
Schlagworte:
Aging - genetics
Aging - metabolism
Animals
Gene Expression Regulation - physiology
Humans
Longevity - genetics
Longevity - physiology
Mutation
Oxygen - metabolism
Protein Isoforms
Review
Shc Signaling Adaptor Proteins - metabolism
Src Homology 2 Domain-Containing, Transforming Protein 1
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Zusammenfassung:Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.100057