Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

Summary Background Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout. Methods Genome-wide association studies were done for serum uric acid in 7699 participants in the Framingham cohort and...

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Veröffentlicht in:	The Lancet (British edition) 2008-12, Vol.372 (9654), p.1953-1961
Hauptverfasser:	Dehghan, Abbas, MD, Köttgen, Anna, MD, Yang, Qiong, PhD, Hwang, Shih-Jen, PhD, Kao, WH Linda, PhD, Rivadeneira, Fernando, MD, Boerwinkle, Eric, PhD, Levy, Daniel, MD, Hofman, Albert, MD, Astor, Brad C, PhD, Benjamin, Emelia J, MD, van Duijn, Cornelia M, PhD, Witteman, Jacqueline C, PhD, Coresh, Josef, MD, Fox, Caroline S, Dr
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Chromosomes, Human, 4-5 - genetics Chromosomes, Human, 6-12 and X - genetics Chronic illnesses Cohort Studies Eye diseases Family physicians Female Genetic research Genetics, Population Genome, Human - genetics Genome-Wide Association Study Genotype Gout - epidemiology Gout - etiology Gout - genetics Humans Hyperuricemia - complications Hyperuricemia - genetics Hyperuricemia - metabolism Internal Medicine Male Medical ethics Middle Aged Netherlands Polymorphism, Single Nucleotide - genetics Prevalence Risk Factors Sample size Studies Systematic review Uric Acid - blood
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Zusammenfassung:	Summary Background Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout. Methods Genome-wide association studies were done for serum uric acid in 7699 participants in the Framingham cohort and in 4148 participants in the Rotterdam cohort. Genome-wide significant single nucleotide polymorphisms (SNPs) were replicated in white (n=11 024) and black (n=3843) individuals who took part in the study of Atherosclerosis Risk in Communities (ARIC). The SNPs that reached genome-wide significant association with uric acid in either the Framingham cohort (p
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(08)61343-4