Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Artery Bypass Graft Surgery

Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Artery Bypass Graft Surgery Simon C. Body, MBChB, MPH ; Charles D. Collard, MD ; Stanton K. Shernan, MD ; Amanda A. Fox, MD ; Kuang-Yu Liu, PhD ; Marylyn D. Ritchie, PhD ; Tjörvi E. Perry, MD, MMSc ; Jochen D. Muehlschlegel, MD ; Sary Aranki, MD ; Brian S. Donahue, MD, PhD ; Mias Pretorius, MBChB ; Juan-Carlos Estrada, MD ; Patrick T. Ellinor, MD, PhD ; Christopher Newton-Cheh, MD, MPH ; Christine E. Seidman, MD ; J.G. Seidman, PhD ; Daniel S. Herman; ; Peter Lichtner, PhD ; Thomas Meitinger, MD ; Arne Pfeufer, MD ; Stefan Kääb, MD ; Nancy J. Brown, MD ; Dan M. Roden, MD and Dawood Darbar, MD From the Department of Anesthesiology, Perioperative and Pain Medicine (S.C.B., S.K.S., A.A.F., K.-Y.L., T.E.P., J.D.M.), Division of Cardiac Surgery (S.A.), Howard Hughes Medical Institute (C.E.S.), Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass; Baylor College of Medicine, Division of Cardiovascular Anesthesia at the Texas Heart Institute (C.D.C.), Saint Luke’s Episcopal Hospital, Houston, Tex; Departments of Anesthesiology (B.S.D., M.P.), Medicine (J.-C.E., D.M.R., N.J.B., D.D.), and Pharmacology (N.J.B., D.M.R.), and Center for Human Genetics Research (M.D.R.), Vanderbilt University School of Medicine, Nashville, Tenn; Department of Genetics (J.G.S., C.E.S., D.S.H.) and the Harvard Medical School—Partners HealthCare Center for Genetics and Genomics (J.G.S.), Harvard Medical School, Boston, Mass; Cardiovascular Research Center (P.T.E., C.N.-C.) and Center for Human Genetic Research (C.N.-C.), Massachusetts General Hospital, Boston, Mass; Program in Medical and Population Genetics (C.N.-C.), Broad Institute of Harvard and MIT, Boston, Mass; Institute of Human Genetics (T.M., P.L., A.P., S.K.), Helmholtz Zentrum München, Neuherberg, and Institute of Human Genetics, Technische Universität München, Munich, Germany; and Medizinische Klinik (S.K.), Klinikum der Universität München–Grosshadern, Munich, Germany. Correspondence to Simon C. Body, MBChB, MPH, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115. E-mail body{at}zeus.bwh.harvard.edu Received January 5, 2009; accepted July 15, 2009. Background— Atrial fibrillation (AF) is the most common adverse event following coronary artery bypass graft surgery. A recent study identified chromosome 4q25 variants associated with AF in ambulatory populati