Heme Transfer to the Bacterial Cell Envelope Occurs via a Secreted Hemophore in the Gram-positive Pathogen Bacillus anthracis

To initiate and sustain an infection in mammals, bacterial pathogens must acquire host iron. However, the host's compartmentalization of large amounts of iron in heme, which is bound primarily by hemoglobin in red blood cells, acts as a barrier to bacterial iron assimilation. Bacillus anthracis...

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Veröffentlicht in:	The Journal of biological chemistry 2009-11, Vol.284 (46), p.32138-32146
Hauptverfasser:	Fabian, Marian, Solomaha, Elena, Olson, John S., Maresso, Anthony W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthrax - genetics Anthrax - metabolism Bacillus anthracis Bacillus anthracis - metabolism Bacterial Proteins - isolation & purification Bacterial Proteins - metabolism Biomolecular Networks Cell Wall - metabolism Chromatography, Affinity Heme - chemistry Heme - metabolism Hemoglobins - metabolism Iron - chemistry Iron - metabolism Staphylococcus aureus
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