In vivo selection of tumor-targeting RNA motifs

In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA...

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Veröffentlicht in:	Nature chemical biology 2010-01, Vol.6 (1), p.22-24
Hauptverfasser:	Sullenger, Bruce A, Clary, Bryan M, Mi, Jing, Liu, Yingmiao, Rabbani, Zahid N, Yang, Zhongguang, Urban, Johannes H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aptamers, Nucleotide - chemistry Biochemical Engineering Biochemistry Bioorganic Chemistry brief-communication Cell Biology Cell Line, Tumor Cercopithecus aethiops Chemistry Chemistry and Materials Science Chemistry/Food Science Colonic Neoplasms - pathology Colonic Neoplasms - therapy Colorectal cancer Colorectal carcinoma COS Cells DEAD-box RNA Helicases - metabolism Gene Expression Regulation, Neoplastic Genetic Techniques Humans Kinetics Liver Neoplasms - secondary Liver Neoplasms - therapy Mice Neoplasm Metastasis Neoplasms - genetics Neoplasms - therapy Oligonucleotides - chemistry Ribonucleic acid RNA RNA - metabolism Rodents Tumors
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Beschreibung
Zusammenfassung:	In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio.277