Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults

Interleukin-6 (IL-6) is an inflammatory cytokine that influences the development of inflammatory and aging-related disorders and ultimately longevity. In order to study the influence of variants in genes that regulate inflammatory response on IL-6 levels and longevity, we screened a panel of 477 tag...

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Veröffentlicht in:Experimental gerontology 2009-05, Vol.44 (5), p.350-355
Hauptverfasser: Walston, Jeremy D., Matteini, Amy M., Nievergelt, Caroline, Lange, Leslie A., Fallin, Dani M., Barzilai, Nir, Ziv, Elad, Pawlikowska, Ludmila, Kwok, Pui, Cummings, Steve R., Kooperberg, Charles, LaCroix, Andrea, Tracy, Russell P., Atzmon, Gil, Lange, Ethan M., Reiner, Alex P.
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Sprache:eng
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Zusammenfassung:Interleukin-6 (IL-6) is an inflammatory cytokine that influences the development of inflammatory and aging-related disorders and ultimately longevity. In order to study the influence of variants in genes that regulate inflammatory response on IL-6 levels and longevity, we screened a panel of 477 tag SNPs across 87 candidate genes in >5000 older participants from the population-based Cardiovascular Health Study (CHS). Baseline plasma IL-6 concentration was first confirmed as a strong predictor of all-cause mortality. Functional alleles of the IL6R and PARP1 genes were significantly associated with 15%–20% higher baseline IL-6 concentration per copy among CHS European–American (EA) participants (all p
ISSN:0531-5565
1873-6815
1873-6815
DOI:10.1016/j.exger.2009.02.004