DNA Responds to Ionizing Radiation as an Insulator, Not as a "Molecular Wire"

DNA Responds to Ionizing Radiation as an Insulator, Not as a "Molecular Wire"

The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 μmol J−1) and insensitive to long‐range (>106 base pairs) versus short‐range stacking (8 base pai...

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Veröffentlicht in:Angewandte Chemie International Edition 1999-09, Vol.38 (18), p.2752-2756
Hauptverfasser: Debije, Michael G., Milano, Michael T., Bernhard, William A.
Format: Artikel
Sprache:eng
Schlagworte:
DNA structures
Electron transfer
EPR spectroscopy
Nucleotides
Radicals
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Zusammenfassung:The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 μmol J−1) and insensitive to long‐range (>106 base pairs) versus short‐range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a “molecular wire”.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/(SICI)1521-3773(19990917)38:18<2752::AID-ANIE2752>3.0.CO;2-U