Efficacy of vitamin B-6 in the treatment of premenstrual syndrome:systematic review
Objective: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. Design: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects: Nine published trials re...
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| Veröffentlicht in: | BMJ 1999-05, Vol.318 (7195), p.1375-1381 |
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| creator | Wyatt, Katrina M Dimmock, Paul W Jones, Peter W O'Brien, P M Shaughn |
| description | Objective: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. Design: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects: Nine published trials representing 940 patients with premenstrual syndrome. Main outcome measures: Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo. Results: Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients. Conclusion: Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression. |
| doi_str_mv | 10.1136/bmj.318.7195.1375 |
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Design: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects: Nine published trials representing 940 patients with premenstrual syndrome. Main outcome measures: Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo. Results: Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients. Conclusion: Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression.</description><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.318.7195.1375</identifier><identifier>PMID: 10334745</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Depressive disorders ; Dosage ; Experimentation ; Female ; Humans ; Mastodynia ; Oral contraceptives ; Placebos ; Premenstrual syndrome ; Premenstrual Syndrome - drug therapy ; Pyridoxine - therapeutic use ; Randomized Controlled Trials as Topic ; Side effects ; Symptoms ; Treatment Outcome ; Vitamins</subject><ispartof>BMJ, 1999-05, Vol.318 (7195), p.1375-1381</ispartof><rights>1999 BMJ Publishing Group Ltd.</rights><rights>Copyright 1999 BMJ</rights><rights>Copyright: 1999 (c) 1999 BMJ Publishing Group Ltd.</rights><rights>Copyright © 1999, British Medical Journal 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b518t-48743066a095aa58c4132df505df54a5d309d7cfb8fa7ea5b5653e6495ea233a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25184702$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25184702$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10334745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wyatt, Katrina M</creatorcontrib><creatorcontrib>Dimmock, Paul W</creatorcontrib><creatorcontrib>Jones, Peter W</creatorcontrib><creatorcontrib>O'Brien, P M Shaughn</creatorcontrib><title>Efficacy of vitamin B-6 in the treatment of premenstrual syndrome:systematic review</title><title>BMJ</title><addtitle>BMJ</addtitle><description>Objective: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. Design: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects: Nine published trials representing 940 patients with premenstrual syndrome. Main outcome measures: Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo. Results: Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients. Conclusion: Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression.</description><subject>Depressive disorders</subject><subject>Dosage</subject><subject>Experimentation</subject><subject>Female</subject><subject>Humans</subject><subject>Mastodynia</subject><subject>Oral contraceptives</subject><subject>Placebos</subject><subject>Premenstrual syndrome</subject><subject>Premenstrual Syndrome - drug therapy</subject><subject>Pyridoxine - therapeutic use</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Side effects</subject><subject>Symptoms</subject><subject>Treatment Outcome</subject><subject>Vitamins</subject><issn>0959-8138</issn><issn>1468-5833</issn><issn>1756-1833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUU2P0zAQtRCIrcr-AA6gSEicSLHjz6C9QFk-xAoOlL1ak8RhXZqk2E6h_56JsqoWLvjgsfTe87yZR8hjRleMcfWy6rYrzsxKs1KuGNfyHlkwoUwuDef3yYKWsswN4-aMnMe4pZQWXJtSyYfkjFHOhRZyQb5etq2voT5mQ5sdfILO99mbXGVY0o3LUnCQOtenCd8Hh8-Ywgi7LB77JgydexWPMbkOkq-z4A7e_XpEHrSwi-78ti7Jt3eXm_WH_OrL-4_r11d5JZlJuTBacKoUoFMAaWrBeNG0kkq8BMiG07LRdVuZFrQDWUkluVOilA4KzoEvycX8736sOtfU6DLAzu6D7yAc7QDe_o30_sZ-Hw620EYblD-_lYfh5-hisp2PtdvtoHfDGK0qtcKOEonP_iFuhzH0OJplGs-0cIEsNrPqMMQYXHsywqidErOYmMXE7JSYnRJDzdO7E9xRzPkg4clM2MY0hBNe4AKFxkCXJJ9xjxn8PuEQflilsYP9fL2215uNpp-0sG-R_2LmT17-7-8PcAG5Fw</recordid><startdate>19990522</startdate><enddate>19990522</enddate><creator>Wyatt, Katrina M</creator><creator>Dimmock, Paul W</creator><creator>Jones, Peter W</creator><creator>O'Brien, P M Shaughn</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><general>British Medical Journal</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>LK8</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990522</creationdate><title>Efficacy of vitamin B-6 in the treatment of premenstrual syndrome:systematic review</title><author>Wyatt, Katrina M ; Dimmock, Paul W ; Jones, Peter W ; O'Brien, P M Shaughn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b518t-48743066a095aa58c4132df505df54a5d309d7cfb8fa7ea5b5653e6495ea233a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Depressive disorders</topic><topic>Dosage</topic><topic>Experimentation</topic><topic>Female</topic><topic>Humans</topic><topic>Mastodynia</topic><topic>Oral contraceptives</topic><topic>Placebos</topic><topic>Premenstrual syndrome</topic><topic>Premenstrual Syndrome - drug therapy</topic><topic>Pyridoxine - therapeutic use</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Side effects</topic><topic>Symptoms</topic><topic>Treatment Outcome</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wyatt, Katrina M</creatorcontrib><creatorcontrib>Dimmock, Paul W</creatorcontrib><creatorcontrib>Jones, Peter W</creatorcontrib><creatorcontrib>O'Brien, P M Shaughn</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wyatt, Katrina M</au><au>Dimmock, Paul W</au><au>Jones, Peter W</au><au>O'Brien, P M Shaughn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of vitamin B-6 in the treatment of premenstrual syndrome:systematic review</atitle><jtitle>BMJ</jtitle><addtitle>BMJ</addtitle><date>1999-05-22</date><risdate>1999</risdate><volume>318</volume><issue>7195</issue><spage>1375</spage><epage>1381</epage><pages>1375-1381</pages><issn>0959-8138</issn><eissn>1468-5833</eissn><eissn>1756-1833</eissn><abstract>Objective: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. Design: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects: Nine published trials representing 940 patients with premenstrual syndrome. Main outcome measures: Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo. Results: Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients. Conclusion: Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>10334745</pmid><doi>10.1136/bmj.318.7195.1375</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0959-8138 1468-5833 1756-1833 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Alma/SFX Local Collection |
| subjects | Depressive disorders Dosage Experimentation Female Humans Mastodynia Oral contraceptives Placebos Premenstrual syndrome Premenstrual Syndrome - drug therapy Pyridoxine - therapeutic use Randomized Controlled Trials as Topic Side effects Symptoms Treatment Outcome Vitamins |
| title | Efficacy of vitamin B-6 in the treatment of premenstrual syndrome:systematic review |
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