Efficacy of vitamin B-6 in the treatment of premenstrual syndrome:systematic review
Objective: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. Design: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects: Nine published trials re...
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Veröffentlicht in: | BMJ 1999-05, Vol.318 (7195), p.1375-1381 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objective: To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome. Design: Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome. Subjects: Nine published trials representing 940 patients with premenstrual syndrome. Main outcome measures: Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo. Results: Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients. Conclusion: Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression. |
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ISSN: | 0959-8138 1468-5833 1756-1833 |
DOI: | 10.1136/bmj.318.7195.1375 |