Trypanosoma cruzi: Antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro

American trypanosomiasis (Chagas disease) continues to be a significant public health problem, and the therapeutic potential of current antichagasic agents (nifurtimox and benznidazole) is rather limited. Here we report on the antitrypanosomal effect of 1-methoxyspirobrassinol and other indole phyto...

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Veröffentlicht in:	Experimental parasitology 2009-05, Vol.122 (1), p.66-69
Hauptverfasser:	Mezencev, Roman, Galizzi, Melina, Kutschy, Peter, Docampo, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	1-methoxyspirobrassinol amastigotes Animal, plant and microbial ecology Animals Antiprotozoal Agents - pharmacology antitrypanosomal activity Applied ecology bioactive properties Biological and medical sciences Brassicaceae Chagas disease Drug Evaluation, Preclinical Ecotoxicology, biological effects of pollution Fundamental and applied biological sciences. Psychology Glutathione growth inhibition in vitro culture Indole phytoalexins indoles Indoles - chemistry Indoles - pharmacology inhibitors Inhibitory Concentration 50 Life cycle. Host-agent relationship. Pathogenesis Myoblasts - drug effects Myoblasts - parasitology new drugs Phytoalexins Protozoa Rats secondary metabolites Sesquiterpenes Spiro Compounds - chemistry Spiro Compounds - pharmacology Structure-Activity Relationship Techniques Terpenes - pharmacology Thiazoles - chemistry Thiazoles - pharmacology Thiocarbamates - chemistry Thiocarbamates - pharmacology trypanocides Trypanosoma cruzi Trypanosoma cruzi - drug effects
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Zusammenfassung:	American trypanosomiasis (Chagas disease) continues to be a significant public health problem, and the therapeutic potential of current antichagasic agents (nifurtimox and benznidazole) is rather limited. Here we report on the antitrypanosomal effect of 1-methoxyspirobrassinol and other indole phytoalexins—secondary metabolites produced by Cruciferous plants. These compounds, that previously demonstrated antimicrobial and anticancer properties, displayed significant antiproliferative effects on intracellular amastigotes of Trypanosoma cruzi and may be prospective candidates for antichagasic drug design and development.
ISSN:	0014-4894 1090-2449
DOI:	10.1016/j.exppara.2009.01.013