Cardiac T2 Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Major

Cardiac T2 Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Major

The goal of this study was to determine the predictive value of cardiac T2* magnetic resonance for heart failure and arrhythmia in thalassemia major. We analyzed cardiac and liver T2* magnetic resonance and serum ferritin in 652 thalassemia major patients from 21 UK centers with 1442 magnetic resona...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2009-11, Vol.120 (20), p.1961-1968
Hauptverfasser: KIRK, P, ROUGHTON, M, PENNELL, D. J, PORTER, J. B, WALKER, J. M, TANNER, M. A, PATEL, J, WU, D, TAYLOR, J, WESTWOOD, M. A, ANDERSON, L. J
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Arrhythmias, Cardiac - blood
Arrhythmias, Cardiac - diagnostic imaging
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - etiology
beta-Thalassemia - blood
beta-Thalassemia - complications
beta-Thalassemia - diagnostic imaging
beta-Thalassemia - epidemiology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Ferritins - blood
Follow-Up Studies
Heart
Heart Failure - blood
Heart Failure - diagnostic imaging
Heart Failure - epidemiology
Heart Failure - etiology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemosiderosis - blood
Hemosiderosis - diagnostic imaging
Hemosiderosis - epidemiology
Humans
Iron - metabolism
Liver - diagnostic imaging
Liver - metabolism
Magnetic Resonance Imaging
Male
Medical sciences
Predictive Value of Tests
Radiography
Retrospective Studies
Risk Factors
United Kingdom - epidemiology
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Zusammenfassung:The goal of this study was to determine the predictive value of cardiac T2* magnetic resonance for heart failure and arrhythmia in thalassemia major. We analyzed cardiac and liver T2* magnetic resonance and serum ferritin in 652 thalassemia major patients from 21 UK centers with 1442 magnetic resonance scans. The relative risk for heart failure with cardiac T2* values 10 ms) was 160 (95% confidence interval, 39 to 653). Heart failure occurred in 47% of patients within 1 year of a cardiac T2*
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.109.874487