Protein Kinase Mzeta Maintains Fear Memory in the Amygdala but Not in the Hippocampus

Recent work on the long-term stability of memory and synaptic plasticity has identified a potentially critical role for protein kinase Mzeta (PKMζ). PKMζ is a constitutively active, atypical isoform of protein kinase C that is believed to maintain long term potentiation at hippocampal synapses in vitro. In behaving animals, local inhibition of PKMζ disrupts spatial memory in the hippocampus and conditioned taste aversion memory in the insular cortex. The role of PKMζ in context fear memory is less clear. This study examined the role of PKMζ in amygdala and hippocampal neurons following a standard fear conditioning protocol. The results indicate that PKMζ inhibition in the amygdala, but not in the hippocampus, can disrupt fear memory. This suggests that PKMζ may only maintain select forms of memory in specific brain structures and does not participate in a universal memory storage mechanism.