Cortical Enlightenment: Are Attentional Gamma Oscillations Driven by ING or PING?

The response of a neuron to sensory stimuli can only give correlational support for functional hypotheses. To experimentally test causal function, the neural activity needs to be manipulated in a cell-type-specific as well as spatially and temporally precise way. We review recent optogenetic experim...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2009-09, Vol.63 (6), p.727-732
Hauptverfasser:	Tiesinga, Paul, Sejnowski, Terrence J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Attention - physiology Biological Clocks - physiology Brain Cerebral Cortex - cytology Experiments Humans Hypotheses Interneurons - physiology Models, Neurological Nerve Net - physiology Neural Inhibition - physiology Neural Pathways - physiology Neurons Space Perception - physiology Studies
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Beschreibung
Zusammenfassung:	The response of a neuron to sensory stimuli can only give correlational support for functional hypotheses. To experimentally test causal function, the neural activity needs to be manipulated in a cell-type-specific as well as spatially and temporally precise way. We review recent optogenetic experiments on parvalbumin-positive cortical interneurons that link modeling studies of synchronization to experimental studies on attentional modulation of gamma oscillations in primates.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/j.neuron.2009.09.009